Research and Studies

Cordyceps Mushroom Extract (Cordyceps militaris)

Pharmacological and Therapeutic Potential of Cordyceps with Special Reference to Cordycepin NCBI
Traditional Uses and Medicinal Potential of Cordyceps Sinensis of Sikkim NCBI
Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials NCBI
Toxicological Safety Evaluation of the Cultivated Chinese Cordyceps SCIDIRECT

Lion's Mane Mushroom Extract (Hericium erinaceus) (fruiting body)

Neuronal Health – Can Culinary and Medicinal Mushrooms Help? NCBI
Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia NCBI
Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds PUBMED

Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells PUBMED

Reishi Mushroom Extract (fruiting body)

Ganoderma lucidum (Lingzhi or Reishi) (multiple studies referenced in this article) NCBI
Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits PUBMED

Eleuthero Root Extract Powder (Eleutherococcus senticosus)

Memory Enhancement by Oral Administration of Extract of Eleutherococcus senticosus Leaves and Active Compounds Transferred in the Brain NCBI
A comparative study on root and bark extracts of Eleutherococcus senticosus and their effects on human macrophages SCIDIRECT
Eleuthero (Eleutherococcus senticosus): a review of its effects and mechanisms of action Schisandra Berry ORGBOOST

Extract Powder (Schisandra chinensis)

Potential of Schisandra chinensis (Turcz.) Baill. in Human Health and Nutrition: A Review of Current Knowledge and Therapeutic Perspectives NCBI
Schisandra chinensis Fructus and Its Active Ingredients as Promising Resources for the Treatment of Neurological Diseases PUBMED
Schisandra chinensis Extract Ameliorates Age-Related Muscle Wasting and Bone Loss in Ovariectomized Rats PUBMED
Schisandra Chinensis Berry Extract Protects Against Steatosis by Inhibiting Histone Acetylation in Oleic Acid-Treated HepG2 Cells and in the Livers of Diet-Induced Obese Mice PUBMED
Metabolomics study of the therapeutic mechanism of Schisandra chinensis lignans on aging rats induced by d-galactose PUBMED

Rhodiola Rosea Root Extract Powder

The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms PUBMED
Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study PUBMED
Repeated administration of R. ROSEA extract SHR-5 exerts an anti-fatigue effect that increases mental performance, particularly the ability to concentrate, and decreases cortisol response to awakening stress in burnout patients with fatigue syndrome. A randomised, double-blind, placebo-controlled, parallel-group study in the treatment of subjects with stress-related fatigue PUBMED
Rhodiola rosea in Subjects with Prolonged or Chronic Fatigue Symptoms: Results of an Open-Label Clinical Trial PUBMED

Bacopa Monnieri Leaf Extract Powder

Bacopa Monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain NCBI
Enhancement of Basolateral Amygdaloid Neuronal Dendritic Arborization Following Bacopa Monniera Extract Treatment in Adult Rats PUBMED
The Chronic Effects of an Extract of Bacopa Monniera (Brahmi) on Cognitive Function in Healthy Human Subjects PUBMED
The Ayurvedic Plant Bacopa Monnieri Inhibits Inflammatory Pathways in the Brain NCBI
Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers PUBMED
An Open-Label Study to Elucidate the Effects of Standardized Bacopa Monnieri Extract in the Management of Symptoms of Attention-Deficit Hyperactivity Disorder in Children PUBMED

Ginkgo Biloba Leaf Extract Powder

Ginkgo biloba Extract in Vascular Protection: Molecular Mechanisms and Clinical Applications PUBMED
Characterization of Ginkgo biloba Leaf Flavonoids as Neuroexocytosis Regulators PUBMED
Oral Supplements of Ginkgo biloba Extract Alleviate Neuroinflammation, Oxidative Impairments and Neurotoxicity in Rotenone-Induced Parkinsonian Rats PUBMED
Neuroprotective and Antioxidant Effect of Ginkgo Biloba Extract Against AD and Other Neurological Disorders NCBI

Ashwagandha Root Extract Powder (Withania somnifera)

An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda PUBMED
Ashwagandha in Brain Disorders: A review of Recent Developments PUBMED
Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions PUBMED
An Investigation into the Stress-Relieving and Pharmacological Actions of an Ashwagandha (Withania somnifera) Extract NCBI
Combinations of Ashwagandha Leaf Extracts Protect Brain-Derived Cells against Oxidative Stress and Induce Differentiation NCBI
A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults PUBMED
Examining the Effect of Withania Somnifera Supplementation on Muscle Strength and Recovery: a Randomized Controlled Trial PUBMED


L-Theanine Reduces Psychological and Physiological Stress Responses PUBMED
Effects of Dietary Threonine Levels on Intestinal Immunity and Antioxidant Capacity Based on Cecal Metabolites and Transcription Sequencing of Broiler NCBI
Sleep-Promoting Effects of Threonine link Amino Acid Metabolism in Drosophila Neuron to GABAergic Control of Sleep Drive NCBI

Guarana Seed Extract Powder (Paullinia cupana)

Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways NCBI
Mechanisms Involved in Anti-Aging Effects of Guarana (Paullinia cupana) in Caenorhabditis Elegans NCBI


Phosphatidylserine and the Human Brain PUBMED
Phosphatidylserine in the Brain: Metabolism and Function NCBI
Phosphatidylserine: an Antidepressant or a Cognitive Enhancer? PUBMED
A Phosphatidylserine Source of Docosahexanoic Acid Improves Neurodevelopment and Survival of Preterm Pigs MDPI

Choline (as Choline L-Bitartrate)

Choline: Critical Role During Fetal Development and Dietary Requirements in Adults PUBMED
Choline and Human Nutrition PUBMED
Dietary Choline Intake: Current State of Knowledge Across the Life Cycle NCBI
Neuroprotective Actions of Dietary Choline NCBI
The Underconsumed and Underappreciated Essential Nutrient NCBI

Magnesium (as Magnesium Glycinate)

The Role of Magnesium in Neurological Disorders NCBI
Magnesium in Prevention and Therapy PUBMED
Therapeutic Uses of Magnesium PUBMED
Magnesium and the Athlete PUBMED
Assessment of cognitive function following magnesium therapy in the traumatically injured brain. SSCHOLAR

Niacin (as Niacinamide)

Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications NCBI
The Influence of Nicotinamide on Health and Disease in the Central Nervous System NCBI
Nicotinamide Riboside, a Trace Nutrient in Foods, is a Vitamin B3 with Effects on Energy Metabolism and Neuroprotection PUBMED

Vitamin B6 (as Pyridoxal-5-Phosphate)

Vitamin B6 Prevents Excessive Inflammation NCBI
Vitamin B6 and Diabetes: Relationship and Molecular Mechanisms NCBI
B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review PUBMED

Vitamin B12 (as Cyanocobalamin)

Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence NCBI
Vitamin B12 in Relation to Oxidative Stress: A Systematic Review NCBI
Vitamin B12 Measurements Across Neurodegenerative Disorders NCBI
Vitamin B12 and Cognitive Function: an Evidence-Based Analysis PUBMED

Vitamin C (as Ascorbic Acid)

Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders NCBI
Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline NCBI
Vitamin C Promotes Oligodendrocytes Generation and Remyelination PUBMED
Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence NCBI
Vitamin C as an antioxidant: evaluation of its role in disease prevention PUBMED
Vitamin C Status and Cognitive Function: A Systematic Review NCBI

Vitamin E (as d-alpha-Tocopheryl Acetate)

Vitamin E Supplementation Reduces Cellular Loss in the Brain of a Premature Aging Mouse Model NCBI
Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease NCBI
Role of Vitamin E in the Treatment of Alzheimer’s Disease: Evidence from Animal Models NCBI
Vitamin E and Neurodegeneration PUBMED